Topical CTC-96 accelerates wart growth in rabbits infected with cottontail rabbit papillomavirus
| Autor: | Ronald C. McGlennen, Ronald S. Ostrow, Susan Coughlin, Zhanjiang Liu, Daniel Zelterman, Anthony J. Faras |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Administration
Topical medicine.medical_treatment Model system Placebo Antiviral Agents Cottontail rabbit papillomavirus Virus Virology Organometallic Compounds medicine Animals Cobalt compounds Pharmacology Chemotherapy Lagomorpha Dose-Response Relationship Drug biology business.industry Papillomavirus Infections virus diseases biology.organism_classification Disease Models Animal Tumor Virus Infections Female Rabbits Viral disease Warts business |
| Zdroj: | Antiviral Research. 24:27-35 |
| ISSN: | 0166-3542 |
| DOI: | 10.1016/0166-3542(94)90049-3 |
| Popis: | CTC-96, a cobalt containing complex, was tested as a putative topical therapeutic agent for the treatment of papillomavirus-induced tumors in our cottontail rabbit papillomavirus (CRPV)-rabbit model system. Following experimental infection of domestic rabbits with CRPV, CTC-96 was applied to infection sites twice daily, 5 days a week for a total of 8 weeks. Two levels of concentrations of aqueous CTC-96 were compared to placebo control-treated animals. With increasing dose of CTC-96 we observed tumors earlier, larger, and more often across eight infected sites on each animal. |
| Databáze: | OpenAIRE |
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