Neuropeptide levels in the basal ganglia of aged common marmosets following prolonged treatment with MPTP
| Autor: | Stephen E. Rose, C. D. Marsden, Michael D. Taylor, P. N. Chong, M. L. de Ceballos, Peter Jenner |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Aging Dopamine Enkephalin Methionine Caudate nucleus Neuropeptide Striatum Substance P Globus Pallidus Basal Ganglia Sincalide chemistry.chemical_compound Reference Values Internal medicine Basal ganglia medicine Animals Biogenic Monoamines Biological Psychiatry Neurotensin General Neuroscience MPTP Putamen Homovanillic acid Neuropeptides Callithrix Homovanillic Acid Psychiatry and Mental health Endocrinology nervous system Neurology chemistry 1-Methyl-4-phenyl-1 2 3 6-tetrahydropyridine 3 4-Dihydroxyphenylacetic Acid Female Neurology (clinical) Caudate Nucleus hormones hormone substitutes and hormone antagonists medicine.drug Enkephalin Leucine |
| Zdroj: | Journal of neural transmission. Parkinson's disease and dementia section. 3(2) |
| ISSN: | 0936-3076 |
| Popis: | Aged common marmosets were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 0.5-2.0 mg/kg/week i.p.) for 16 or 24 weeks, observed for a total of 30 weeks and then killed for measurement of biochemical parameters in basal ganglia. The MPTP treatment induced a marked depletion in dopamine, 3,4-dihydroxyphenylacetic acid and homovanillic acid levels in the caudate nucleus and putamen. In contrast, the concentrations of five neuropeptides: [Met5]-enkephalin, [Leu5]-enkephalin, cholecystokinin, substance P and neurotensin as measured by a combined HPLC/RIA method, remained unaltered in all basal ganglia regions examined. Enkephalin precursor levels, as reflected by cryptic [Met5]-enkephalin content, were increased in the putamen, but not in the caudate nucleus, as a consequence of MPTP administration. Cryptic [Leu5]-enkephalin content remained unchanged in the striatum of MPTP treated marmosets. Overall, these results suggest an increase in striatal [Met5]-enkephalin release following chronic MPTP treatment of aged marmosets. However, the chronic treatment of aged marmosets with MPTP does not reproduce the neuropeptide alterations characteristic of Parkinson's disease. |
| Databáze: | OpenAIRE |
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