Atorvastatin Induced Erythrocytes Membrane Blebbing
| Autor: | Asma Asghar, Ismat Bibi, Mazhar Hussain Ranjha, Muhammad Riaz, Muhammad Irfan, Rumaisa Bashir Rana, Kashif Jilani, Muhammad Shahid |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Health Toxicology and Mutagenesis Atorvastatin chemistry.chemical_element Pharmacology Calcium Reductase Toxicology medicine.disease_cause Superoxide dismutase 03 medical and health sciences 0302 clinical medicine eryptosis medicine oxidative stress chemistry.chemical_classification Chemical Health and Safety calcium biology Chemistry Glutathione peroxidase lcsh:RM1-950 Public Health Environmental and Occupational Health nutritional and metabolic diseases Calcium Channel Inhibition cell size 030104 developmental biology lcsh:Therapeutics. Pharmacology Catalase 030220 oncology & carcinogenesis biology.protein lipids (amino acids peptides and proteins) Original Article Oxidative stress medicine.drug |
| Zdroj: | Dose-Response Dose-Response, Vol 17 (2019) |
| ISSN: | 1559-3258 |
| Popis: | Atorvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzymeA reductase, is usually used for the treatment of hypercholesterolemia. Besides its pharmacological and side actions, its toxic effects on human nucleus devoid of erythrocytes are still unknown. Eryptosis is an alternative term used for suicidal erythrocyte death. Membrane blebbing is among the common markers of eryptosis. In this study, eryptotic effect of atorvastatin was investigated by exposing the erythrocytes for 48 hours to different concentrations (1-10 µM) of atorvastatin. The experimental work related to investigation of eryptosis was done by cell size measurement and calcium channel inhibition. As a possible mechanism of eryptosis, atorvastatin-induced oxidative stress was evaluated by determining catalase, glutathione peroxidase, and superoxide dismutase activities. Similarly, necrotic effect of atorvastatin was also determined by hemolytic assay. Results of our study illustrated that the tested doses of atorvastatin may induce oxidative stress as observed by significant reduction in superoxide dismutase, glutathione peroxidase, and catalase activities as well as induce eryptosis, featured by erythrocytes membrane blebbing. The study concluded that induction of oxidative stress by atorvastatin may lead to eryptosis. |
| Databáze: | OpenAIRE |
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