Characterization of anti-EBA175RIII-V in asymptomatic adults and children living in communities in the Greater Accra Region of Ghana with varying malaria transmission intensities
| Autor: | Hamza B. Abagna, Aminata Colle Lo, Ben Gyan, Linda E. Amoah, Kwadwo A. Kusi, Kwadwo Akyea-Mensah |
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| Rok vydání: | 2018 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Adult Male 0301 basic medicine Erythrocytes Adolescent Plasmodium falciparum 030231 tropical medicine Immunology Protozoan Proteins Antigens Protozoan Ghana Asymptomatic Cohort Studies 03 medical and health sciences 0302 clinical medicine Antigen parasitic diseases Prevalence medicine Humans Parasite hosting Avidity Malaria Falciparum Child Aged biology business.industry Middle Aged medicine.disease biology.organism_classification 030104 developmental biology Carriage Child Preschool Immunoglobulin G biology.protein Female medicine.symptom Antibody lcsh:RC581-607 business Malaria Research Article |
| Zdroj: | BMC Immunology BMC Immunology, Vol 19, Iss 1, Pp 1-9 (2018) |
| ISSN: | 1471-2172 |
| Popis: | Background Antibodies against Region III-V of the erythrocyte binding antigen (EBA) 175 (EBA175RIII-V) have been suggested to provide protection from malaria in a natural infection. However, the quality and quantity of naturally induced antibodies to EBA175RIII-V has not been fully characterized in different cohorts of Ghanaians. This study sought to determine the characteristics of antibodies against EBA175RIII-V in asymptomatic adults and children living in two communities of varying P. falciparum parasite prevalence in southern Ghana. Methods Microscopic evaluation of thick and thin blood smears was used to identify asymptomatic Plasmodium falciparum carriage and indirect enzyme linked immunosorbent (ELISA) used to assess antibody concentrations and avidity. Results Parasite carriage estimated by microscopy in Obom was 35.6% as opposed to 3.5% in Asutsuare. Levels of IgG, IgG1, IgG2, IgG3 and IgG4 against EBA175RIII-V in the participants from Obom were significantly higher (P |
| Databáze: | OpenAIRE |
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