Iloprost improves femoro-distal graft flow after a single bolus injection
| Autor: | M.H. Simms, M. C. Crowson, N.C. Hickey, H.R. Watson, C. P. Shearman |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Graft flow Graft failure Prostacyclin Placebo Arteriovenous Shunt Surgical Double-Blind Method Humans Medicine Saphenous Vein Iloprost Aged business.industry Ultrasound Graft Occlusion Vascular Blood flow Femoral Artery Single bolus Regional Blood Flow Anesthesia Female lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine business Blood Flow Velocity medicine.drug |
| Zdroj: | European Journal of Vascular Surgery. 5:19-22 |
| ISSN: | 0950-821X |
| DOI: | 10.1016/s0950-821x(05)80921-1 |
| Popis: | A double-blind, randomised, placebo-controlled trial was conducted to study the effect of the stable prostacyclin analogue iloprost on femoro-distal graft blood flow. After completing femoro-distal reconstruction, 3000 ng of iloprost or placebo was injected into the graft over 2 min. Graft blood flow, measured by electromagnetic flowmetry, increased by a mean (range) of 94% (12 to 192%) in patients receiving iloprost (n = 15) compared to 6% (-34 to 53%) in controls (n = 16; p less than 0.0001, t-test). Increased graft flow, measured by duplex ultrasound, was maintained in the iloprost group over a 7 day period postoperatively (F = 5.2, p = 0.03; analysis of variance) and remained higher at 7 days (p = 0.007, t-test). Iloprost produces an immediate, sustained increase in graft blood flow after femoro-distal reconstruction and may therefore be of benefit in reducing the incidence of early graft failure. |
| Databáze: | OpenAIRE |
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