Synthesis, characterization and cytotoxicity of mixed ligand Mn(II), Co(II) and Ni(II) complexes
| Autor: | Abdallah A. El-Sawy, Taghrid S. Hafez, Yosef Hisham A. Abdallah, Ashraf S. Hassan, Mohamed M. Abdallah, Hanan A. Mousa, Souad A. Osman |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
mixed ligands
Stereochemistry Acetylacetone Isatin Sulforhodamine B Molar conductivity General Chemistry Chloride isatin transition metals Metal 3-(2-(aryl)hydrazono)acetylacetone lcsh:Chemistry chemistry.chemical_compound chemistry Transition metal lcsh:QD1-999 visual_art visual_art.visual_art_medium medicine cytotoxicity Cytotoxicity medicine.drug Nuclear chemistry |
| Zdroj: | Journal of the Serbian Chemical Society, Vol 79, Iss 8, Pp 953-964 (2014) |
| ISSN: | 1820-7421 0352-5139 |
| Popis: | Complexes of the type [ML'L(OH)(H2O)] {where M= Ni(II), Co(II) or Mn(II), L'= isatin and HL= 3-(2-phenylhydrazono)acetylacetone, 3-(2-(4-chlorophenyl)hydrazono)acetylacetone or 3-(2-(4-bromophenyl)hydrazono)-acetylacetone} have been synthesized by equimolar reaction of a metal(II) chloride with isatin and 3-(2-(aryl)hydrazono)acetylacetone. The resulting complexes have been characterized by elemental analyses, molar conductivity, spectral data (IR, 1H NMR, mass) and magnetic moments. Furthermore, the ligands and their metal complexes have been screened for their cytotoxicity against different human cancer cell lines by using SRB assay. The results showed that most of the mixed ligand metal complexes have high cytotoxicity in comparison with the reference drugs used. |
| Databáze: | OpenAIRE |
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