Distribution and morphology of baroreceptors in the rat carotid sinus as revealed by immunohistochemistry for P2X3 purinoceptors
| Autor: | Takuya Yokoyama, Nobuaki Nakamuta, Yoshio Yamamoto, Kazuya Settai |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Histology Baroreceptor Pressoreceptors 03 medical and health sciences medicine.artery medicine Animals P2X purinoreceptor Rats Wistar Axon Molecular Biology 030102 biochemistry & molecular biology biology Chemistry Carotid sinus Cell Biology Anatomy Immunohistochemistry Rats Myelin basic protein body regions Medical Laboratory Technology Carotid Sinus 030104 developmental biology medicine.anatomical_structure nervous system biology.protein Carotid body Internal carotid artery Free nerve ending Receptors Purinergic P2X3 |
| Zdroj: | Histochemistry and Cell Biology. 151:161-173 |
| ISSN: | 1432-119X 0948-6143 |
| DOI: | 10.1007/s00418-018-1734-1 |
| Popis: | The morphological characteristics of baroreceptors in the rat carotid sinus were reevaluated by whole-mount preparations with immunohistochemistry for P2X3 purinoceptors using confocal scanning laser microscopy. Immunoreactive nerve endings for P2X3 were distributed in the internal carotid artery proximal to the carotid bifurcation, particularly in the region opposite the carotid body. Some pre-terminal axons in nerve endings were ensheathed by myelin sheaths immunoreactive for myelin basic protein. Pre-terminal axons ramified into several branches that extended two-dimensionally in every direction. The axon terminals of P2X3-immunoreactive nerve endings were flat and leaf-like in shape, and extended hederiform- or knob-like protrusions in the adventitial layer. Some axons and axon terminals with P2X3 immunoreactivity were also immunoreactive for P2X2, and axon terminals were closely surrounded by terminal Schwann cells with S100 or S100B immunoreactivity. These results revealed the detailed morphology of P2X3-immunoreactive nerve endings and suggested that these endings respond to a mechanical deformation of the carotid sinus wall with their flat leaf-like terminals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink