Combined mucosal and systemic immunity following pulmonary delivery of ISCOMATRIX adjuvanted recombinant antigens
| Autor: | Ana Vujanic, Jean-Pierre Y. Scheerlinck, Kenneth J. Snibson, Margaret Bridget Holland Moloney, Stirling John Edwards, Philip Sutton, Charles Quinn, Martin J. Pearse, Janet L. Wee, Shirley Taylor |
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| Rok vydání: | 2009 |
| Předmět: |
Injections
Subcutaneous Antibodies Viral law.invention Immune system Antigen Adjuvants Immunologic Viral Envelope Proteins Immunity law Administration Inhalation Animals Lymphocytes Antigens Viral Phospholipids Cell Proliferation Antigens Bacterial Vaccines Synthetic Sheep General Veterinary General Immunology and Microbiology biology Helicobacter pylori Public Health Environmental and Occupational Health Saponins biology.organism_classification Catalase Virology Antibodies Bacterial Vaccination Drug Combinations Infectious Diseases Cholesterol Immunization Immunology Recombinant DNA biology.protein Molecular Medicine Female Antibody |
| Zdroj: | Vaccine. 28(14) |
| ISSN: | 1873-2518 |
| Popis: | Deep pulmonary delivery of an influenza ISCOMATRIX™ vaccine has previously been shown to induce a combined mucosal and systemic antibody response. To explore whether this combined response is influenced by intrinsic properties of the component antigen, we examined the efficacy of deep pulmonary delivery of ISCOMATRIX™ vaccines containing different recombinant antigens, specifically gB glycoprotein from cytomegalovirus and a fragment of catalase from Helicobacter pylori. Both these vaccines induced antigen-specific mucosal and systemic immunity, as well as antigen-specific proliferative cellular responses. Pulmonary immunisation with ISCOMATRIX™ vaccines may therefore be a generic way of inducing combined systemic and mucosal immunity. |
| Databáze: | OpenAIRE |
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