Definition of common carotid wall thickness affects risk classification in relation to degree of internal carotid artery stenosis : the Plaque At RISK (PARISK) study

Autor: Werner H. Mess, Paul J. Nederkoorn, J. Steinbuch, Arnold P.G. Hoeks, Martine T. B. Truijman, Floris H.B.M. Schreuder, A.C. van Dijk, Jeroen Hendrikse, A. van der Lugt, Evelien Hermeling
Přispěvatelé: Amsterdam Neuroscience - Neurovascular Disorders, Neurology, ACS - Atherosclerosis & ischemic syndromes, Promovendi CD, Klinische Neurowetenschappen, MUMC+: MA AIOS Neurologie (9), Biomedische Technologie, MUMC+: HZC Klinische Neurofysiologie (5), RS: CARIM - R3.11 - Imaging, RS: CARIM - R3.03 - Cerebral small vessel disease, Radiology & Nuclear Medicine
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
Computed Tomography Angiography
PROGRESSION
030204 cardiovascular system & hematology
Carotid Intima-Media Thickness
INTIMA-MEDIA THICKNESS
THERAPY
Cohort Studies
0302 clinical medicine
Medicine
Carotid Stenosis
Common carotid artery
Ultrasonography
Aged
80 and over
Stenosis
medicine.diagnostic_test
HERITABILITY
Ultrasound
ENVIRONMENTAL CONTRIBUTIONS
WOMEN
MEN
General Medicine
Middle Aged
Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3]
Cardiology
cardiovascular system
Female
Carotid artery imaging
Internal carotid artery
Cardiology and Cardiovascular Medicine
Adult
medicine.medical_specialty
Carotid Artery
Common
PHENOTYPES
Carotid IMT
Risk Assessment
Sensitivity and Specificity
03 medical and health sciences
Internal medicine
medicine.artery
Journal Article
Humans
Radiology
Nuclear Medicine and imaging
cardiovascular diseases
Aged
Angiology
business.industry
Surrogate endpoint
Research
medicine.disease
Atherosclerosis
Intima-media thickness
lcsh:RC666-701
Angiography
business
030217 neurology & neurosurgery
Zdroj: Cardiovascular Ultrasound, 15, 9
Cardiovascular ultrasound, 15(1). BioMed Central
Cardiovascular Ultrasound, 15, 1, pp. 9
Cardiovascular Ultrasound, Vol 15, Iss 1, Pp 1-8 (2017)
Cardiovascular Ultrasound, 15:9. BioMed Central Ltd
Cardiovascular Ultrasound, 15:9. BioMed Central Ltd.
Cardiovascular Ultrasound, 15(1). BioMed Central
Cardiovascular Ultrasound
ISSN: 1476-7120
Popis: Contains fulltext : 175960.pdf (Publisher’s version ) (Open Access) BACKGROUND: Mean or maximal intima-media thickness (IMT) is commonly used as surrogate endpoint in intervention studies. However, the effect of normalization by surrounding or median IMT or by diameter is unknown. In addition, it is unclear whether IMT inhomogeneity is a useful predictor beyond common wall parameters like maximal wall thickness, either absolute or normalized to IMT or lumen size. We investigated the interrelationship of common carotid artery (CCA) thickness parameters and their association with the ipsilateral internal carotid artery (ICA) stenosis degree. METHODS: CCA thickness parameters were extracted by edge detection applied to ultrasound B-mode recordings of 240 patients. Degree of ICA stenosis was determined from CT angiography. RESULTS: Normalization of maximal CCA wall thickness to median IMT leads to large variations. Higher CCA thickness parameter values are associated with a higher degree of ipsilateral ICA stenosis (p < 0.001), though IMT inhomogeneity does not provide extra information. When the ratio of wall thickness and diameter instead of absolute maximal wall thickness is used as risk marker for having moderate ipsilateral ICA stenosis (>50%), 55 arteries (15%) are reclassified to another risk category. CONCLUSIONS: It is more reasonable to normalize maximal wall thickness to end-diastolic diameter rather than to IMT, affecting risk classification and suggesting modification of the Mannheim criteria. TRIAL REGISTRATION: Clinical trials.gov NCT01208025 .
Databáze: OpenAIRE
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