Growth arrest specific protein 7 inhibits tau fibrillogenesis
| Autor: | Takafumi Uchida, Chiyoko Uchida, Keiko Hirose, Taiki Shimizu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Protein Conformation Biophysics Nerve Tissue Proteins tau Proteins Fibril Biochemistry Protein Aggregation Pathological WW Domains 03 medical and health sciences Protein Aggregates 0302 clinical medicine Growth Arrest-Specific Protein 7 Protein Domains mental disorders Humans Phosphorylation Molecular Biology Chemistry Fibrillogenesis Neurofibrillary Tangles Cell Biology Cell biology 030104 developmental biology HEK293 Cells Tauopathies 030220 oncology & carcinogenesis Tau phosphorylation Protein Binding |
| Zdroj: | Biochemical and biophysical research communications. 526(2) |
| ISSN: | 1090-2104 |
| Popis: | Here we show that Gas7 inhibits phosphorylated tau fibrillogenesis by binding to phosphorylated tau at its non-WW domain, presumably F-BAR domain. We revealed that Gas7 binds to the third repeat domain of tau, the core element of tau oligomerization and the C-terminal domain of tau and alters the conformation not to form fibrils. These results suggest that Gas7 may serve to protect against Alzheimer's disease and other tauopathies by preventing tau fibrillogenesis. |
| Databáze: | OpenAIRE |
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