Effects of Yak skin gelatin on platelet activation
| Autor: | Yan Li, Xiaoxi Wang, Wei Lixin, Yuzhi Du, Yang Hongxia, Qi Chen |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Blood Platelets
Male 0301 basic medicine food.ingredient Platelet Membrane Glycoproteins Pharmacology Platelet membrane glycoprotein Gelatin Rats Sprague-Dawley Mice 03 medical and health sciences food Animals Platelet Platelet activation CD36 antigen Skin Hemostasis 030109 nutrition & dietetics Chemistry General Medicine Platelet Activation Rats 030104 developmental biology Clotting time Cattle Female Platelet Membrane Glycoprotein IIb Platelet Aggregation Inhibitors Food Science |
| Zdroj: | Food & Function. 10:3379-3385 |
| ISSN: | 2042-650X 2042-6496 |
| DOI: | 10.1039/c8fo02513d |
| Popis: | Studies have shown that gelatin is not only a good hemostatic material, but also a food additive with potentially broad use. Yak skin gelatin is a new gelatin resource, but its oral coagulant effects have not been studied. Given the central role of platelets in hemostasis, in this study we examined the pharmacodynamical differences between different molecular Yak skin gelatins on platelet activation. The hemostatic effects of Yak skin gelatins with different molecular weight distributions were evaluated for bleeding time (BT), clotting time (CT), and platelet activity by measuring the contents of P-selectin, platelet membrane glycoprotein Ia/IIa (GP Ia/IIa), platelet membrane glycoprotein IIb/IIIa (GP IIb/IIIa), and platelet membrane glycoprotein IV (GP IV). Intragastric administration of Yak skin gelatin resulted in a significant reduction in CT and BT, and an increase in the contents of P-selectin, GP Ia/IIa, GP IIb/IIIa, and GP IV in all groups in comparison with the control group. The strongest activation of platelets by Yak skin gelatin was observed with size between 0.1 μm and 0.22 μm, and activation may have been in response to improving GP IIb/IIIa and GP IV levels. When measuring the levels of an established indicator of platelet activation, platelet activation-dependent granule membrane protein (CD62P), its promotion was observed for all molecular weight ranges of Yak skin gelatins. In brief, Yak skin gelatin has hemostatic effects, and Yak skin gelatin fractions between 0.1 μm and 0.22 μm are the primary effectors of hemostasis via promoting platelet membrane glycoprotein activities and strengthening platelet function. |
| Databáze: | OpenAIRE |
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