Three-dimensional volumetric analysis of irradiated lung with adjuvant breast irradiation
| Autor: | Amy Y M Teh, Liang Shen, Eileen J.H. Park, Hans T. Chung |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty medicine.medical_treatment Breast Neoplasms Young Adult Breast cancer Imaging Three-Dimensional medicine Humans Radiology Nuclear Medicine and imaging Stage (cooking) Prospective cohort study Lung Pneumonitis Aged Retrospective Studies Radiation business.industry Incidence (epidemiology) Radiotherapy Planning Computer-Assisted Carcinoma Ductal Breast Radiotherapy Dosage Ductal carcinoma Middle Aged medicine.disease Tumor Burden Radiation therapy Radiation Pneumonitis medicine.anatomical_structure Oncology Female Radiotherapy Adjuvant Radiology Nuclear medicine business Tomography X-Ray Computed Carcinoma in Situ |
| Zdroj: | International journal of radiation oncology, biology, physics. 75(5) |
| ISSN: | 1879-355X |
| Popis: | Purpose To retrospectively evaluate the dose–volume histogram data of irradiated lung in adjuvant breast radiotherapy (ABR) using a three-dimensional computed tomography (3D-CT)–guided planning technique; and to investigate the relationship between lung dose–volume data and traditionally used two-dimensional (2D) parameters, as well as their correlation with the incidence of steroid-requiring radiation pneumonitis (SRRP). Methods and Materials Patients beginning ABR between January 2005 and February 2006 were retrospectively reviewed. Patients included were women aged ≥18 years with ductal carcinoma in situ or Stage I–III invasive carcinoma, who received radiotherapy using a 3D-CT technique to the breast or chest wall (two-field radiotherapy [2FRT]) with or without supraclavicular irradiation (three-field radiotherapy [3FRT]), to 50 Gy in 25 fractions. A 10-Gy tumor-bed boost was allowed. Lung dose–volume histogram parameters (V 10 , V 20 , V 30 , V 40 ), 2D parameters (central lung depth [CLD], maximum lung depth [MLD], and lung length [LL]), and incidence of SRRP were reported. Results A total of 89 patients met the inclusion criteria: 51 had 2FRT, and 38 had 3FRT. With 2FRT, mean ipsilateral V 10 , V 20 , V 30 , V 40 and CLD, MLD, LL were 20%, 14%, 11%, and 8% and 2.0 cm, 2.1 cm, and 14.6 cm, respectively, with strong correlation between CLD and ipsilateral V 10–V40 ( R 2 = 0.73–0.83, p 10 , V 20 , V 30 , and V 40 were 30%, 22%, 17%, and 11%, but its correlation with 2D parameters was poor. With a median follow-up of 14.5 months, 1 case of SRRP was identified. Conclusions With only 1 case of SRRP observed, our study is limited in its ability to provide definitive guidance, but it does provide a starting point for acceptable lung irradiation during ABR. Further prospective studies are warranted. |
| Databáze: | OpenAIRE |
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