Correlation of Antithrombogenicity and Heat Treatment for Layer-by-Layer Self-Assembled Polyelectrolyte Films
| Autor: | Motomi Matsuda, Seimei Shiratori |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Vinyl alcohol
Materials science Swine Layer by layer Mineralogy Membranes Artificial Surfaces and Interfaces Condensed Matter Physics Polyelectrolyte Allylamine chemistry.chemical_compound Adsorption Acrylates Fibrinolytic Agents chemistry Chemical engineering Materials Testing Electrochemistry Animals Polyvinyls General Materials Science Spectroscopy Fibrinolytic agent Acrylic acid Protein adsorption |
| Zdroj: | Langmuir. 27:4271-4277 |
| ISSN: | 1520-5827 0743-7463 |
| DOI: | 10.1021/la200340v |
| Popis: | Antithrombogenic films with high durability were fabricated in a wet process. Antithrombogenicity was achieved with polyelectrolyte multilayer thin film prepared from poly(vinyl alcohol)-poly(acrylic acid) (PVA-PAA) blends, deposited in alternate layers with poly(allylamine hydrochloride) (PAH). Film durability, assessed by abrasion resistance and water resistance, was enhanced by forming cross-links via amide bonds induced by heat treatment of the film. The film was found to be resistant to protein adsorption, as measured by the amount of fibrinogen adsorbed from an aqueous solution. The antithrombogenic efficacy was assessed in ex vivo experiments by the ability of stainless steel mesh, coated with the polyelectrolyte and inserted into a pig blood vessel, to inhibit thrombus formation. Mesh coated with the polyelectrolyte did not reduce blood flow over a period of 15 min, whereas with uncoated mesh blood flow stopped within 6 min because of blood vessel blockage by thrombus formation. |
| Databáze: | OpenAIRE |
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