Differences in clinical manifestations of influenza-associated encephalopathy by age
Autor: | Akihisa Okumura, Mitsuaki Hosoya, Tsuneo Morishima, Masashi Shiomi, Tomoaki Wada, Masato Tashiro, Yoshinobu Okuno |
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Rok vydání: | 2009 |
Předmět: |
Male
Pediatrics medicine.medical_specialty Adolescent Immunology Encephalopathy Microbiology Influenza associated encephalopathy Age Distribution Japan Virology Influenza Human Humans Medicine Encephalitis Viral Child Altered consciousness business.industry Incidence Incidence (epidemiology) Clinical course Infant Odds ratio medicine.disease Confidence interval Surgery Child Preschool Female Age distribution business |
Zdroj: | Microbiology and Immunology. 53:83-88 |
ISSN: | 1348-0421 0385-5600 |
Popis: | Data from patients in Japan was analyzed to examine the age distribution and differences by age in the clinical manifestations of influenza-associated encephalopathy. Between 1998 and 2002, 472 cases of influenza-associated encephalopathy in patients aged 15 years or younger were reported to the Collaborative Study Group on Influenza-Associated Encephalopathy. These cases were divided into two groups by age: 0-5 and 6-15 years. The differences between the groups were estimated based on the data for those aged 0-5 years, and the odds ratios and 95% confidence intervals calculated. Distribution was inversely correlated with age, with a peak at 1-2 years old. In comparison with patients aged 0-5, those aged 6-15 years had a significantly greater incidence of type B infection, lower frequency of convulsions, higher frequency of loss of consciousness and altered consciousness as the initial neurological symptom, lower serum transaminase levels, lower frequency of low-density area for brain CT upon admission, and lower incidence of sequelae. Our analysis indicates that the clinical course, laboratory data, and brain imaging findings of influenza-associated encephalopathy exhibits patterns that vary with age. |
Databáze: | OpenAIRE |
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