Differences in clinical manifestations of influenza-associated encephalopathy by age

Autor: Akihisa Okumura, Mitsuaki Hosoya, Tsuneo Morishima, Masashi Shiomi, Tomoaki Wada, Masato Tashiro, Yoshinobu Okuno
Rok vydání: 2009
Předmět:
Zdroj: Microbiology and Immunology. 53:83-88
ISSN: 1348-0421
0385-5600
Popis: Data from patients in Japan was analyzed to examine the age distribution and differences by age in the clinical manifestations of influenza-associated encephalopathy. Between 1998 and 2002, 472 cases of influenza-associated encephalopathy in patients aged 15 years or younger were reported to the Collaborative Study Group on Influenza-Associated Encephalopathy. These cases were divided into two groups by age: 0-5 and 6-15 years. The differences between the groups were estimated based on the data for those aged 0-5 years, and the odds ratios and 95% confidence intervals calculated. Distribution was inversely correlated with age, with a peak at 1-2 years old. In comparison with patients aged 0-5, those aged 6-15 years had a significantly greater incidence of type B infection, lower frequency of convulsions, higher frequency of loss of consciousness and altered consciousness as the initial neurological symptom, lower serum transaminase levels, lower frequency of low-density area for brain CT upon admission, and lower incidence of sequelae. Our analysis indicates that the clinical course, laboratory data, and brain imaging findings of influenza-associated encephalopathy exhibits patterns that vary with age.
Databáze: OpenAIRE
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