Synthesis of highly functionalized phenylalanine derivatives via cross-enyne metathesis reactions
| Autor: | Enugurthi Brahmachary, Somnath Halder, Sambasivarao Kotha |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Diene
Chemistry Amino-Acid Derivatives Organic Chemistry Metathesis Enyne metathesis Biochemistry Phenylalanine derivatives chemistry.chemical_compound Olefin Metathesis Drug Discovery Organic chemistry Moiety Amino Acids And Derivatives Diels-Alder Reaction Dienes Acyclic diene metathesis Diels–Alder reaction |
| Zdroj: | Tetrahedron. 58:9203-9208 |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/s0040-4020(02)01178-x |
| Popis: | A new method for the synthesis of constrained phenylalanine derivatives is described. In this regard, the simple synthesis of acyclic diene building blocks embodying an alpha-amino acid moiety has been achieved. The diene building blocks have been prepared by cross enyne-metathesis reaction as a key step. The Diels-Alder reaction of the dienes with a dienophile such as dimethyl acetylenedicarboxilate (DMAD) followed by oxidation of the resulting cycloadduct gave highly substituted phenylalanine derivatives. (C) 2002 . . |
| Databáze: | OpenAIRE |
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