Targeting PSG1 to enhance chemotherapeutic efficacy: new application for anti-coagulant the dicumarol

Autor: Feng Gu, Guang yuan Zhang, Chun Xiao Lu, Xin Ma, Jin ke Wang, Jun jun Hao, Xiao Ting Gu, Jian Wu, Dong xu He, Zhong yang Ding, Ai qin Mao, Li Fu
Rok vydání: 2016
Předmět:
Zdroj: Clinical science (London, England : 1979). 130(24)
ISSN: 1470-8736
Popis: Chemotherapeutic response is critical for the successful treatment and good prognosis in cancer patients. In this study, we analysed the gene expression profiles of preoperative samples from oestrogen receptor (ER)-negative breast cancer patients with different responses to taxane-anthracycline-based (TA-based) chemotherapy, and identified a group of genes that was predictive. Pregnancy specific beta-1-glycoprotein 1 (PSG1) played a central role within signalling pathways of these genes. Inhibiting PSG1 can effectively reduce chemoresistance via a transforming growth factor-β (TGF-β)-related pathway in ER-negative breast cancer cells. Drug screening then identified dicumarol (DCM) to target the PSG1 and inhibit chemoresistance to TA-based chemotherapy in vitro, in vivo, and in clinical samples. Taken together, this study highlights PSG1 as an important mediator of chemoresistance, whose effect could be diminished by DCM.
Databáze: OpenAIRE
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