MRI morphometric analysis and neuropsychological function in patients with neurofibromatosis
| Autor: | J. K. Whitt, T.-L. Yeh, Robert S. Greenwood, Sameh M. Said, Larry A. Tupler, K. R. R. Krishnan |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Pathology Adolescent Neurofibromatoses Neuropsychological function Judgment of Line Orientation Neuropsychological Tests Audiology Grey matter White matter Age Distribution medicine Humans In patient Neurofibromatosis Child neoplasms Cerebral Cortex medicine.diagnostic_test General Neuroscience Infant Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging eye diseases nervous system diseases medicine.anatomical_structure Morphometric analysis Child Preschool Female Psychology |
| Zdroj: | NeuroReport. 7:1941-1944 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-199608120-00015 |
| Popis: | Volumes of cerebral gray and white matter were measured in 22 children with neurofibromatosis type 1 (NF1) and in 20 controls. Judgment of Line Orientation (JLO) and the Developmental Test of Visual-Motor Integration (DTVMI) were administered to 16 of the NF1 patients. General linear models analysis of covariance revealed significantly larger brain volumes in NF1 children than in controls, particularly in white matter, and particularly in girls. JLO and DTVMI performance were positively related to right-hemisphere gray-matter volume. The results implicate a failure of growth control in NF1, leading to aberrant neurodevelopment. Our findings also suggest a basis for refined understanding of learning disabilities, which are a prominent feature of NF1. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|