Differentiation of single-cell organisms according to elongation stages crucial for gene expression efficacy
| Autor: | Yuri G. Matushkin, Vitali A. Likhoshvai |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Ribosomal Proteins
Archaeal Proteins Cell Peptide Chain Elongation Translational Biophysics Codon frequency RNA Archaeal Saccharomyces cerevisiae Biology Biochemistry Nucleotide composition Genes Archaeal Fungal Proteins Mathematical model Computer analysis Bacterial Proteins Structural Biology Local complementarity Gene expression Genetics medicine RNA Messenger Codon Molecular Biology Gene Base Composition Messenger RNA Bacteria Models Genetic RNA Fungal Cell Biology Archaea Yeast RNA Bacterial medicine.anatomical_structure Genes Bacterial Elongation Algorithms |
| Zdroj: | FEBS Letters. 516:87-92 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/s0014-5793(02)02507-3 |
| Popis: | We analyzed the interrelation between the efficiency of a gene expression and the nucleotide composition of all protein-coding sequences in 38 unicellular organisms whose complete genomic sequences are known. These organisms comprise 37 prokaryotic (29 eubacteria and eight archaebacteria) and one eukaryotic (yeast) species. We demonstrated that frequency analysis of gene codon composition fails to reflect adequately the gene expression efficiency of all these organisms. We constructed a measure, the elongation efficiency index, that considers simultaneously the information on codon frequencies and the degree of mRNA local self-complementarity. This measure recognizes the ribosome-coding genes as highly expressed in all the unicellular organisms studied. According to our analysis, these species fall into five groups differentiated by the process that makes the key contribution to the elongation rate. |
| Databáze: | OpenAIRE |
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