Effect of sodium depletion on peripheral vascular responses to heat stress in baboons
| Autor: | D. W. Proppe |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
medicine.medical_specialty Hot Temperature Physiology Sodium Hemodynamics chemistry.chemical_element Blood Pressure Body Temperature Renal Circulation Ilium Stress Physiological Physiology (medical) Internal medicine Renin Renin–angiotensin system medicine Animals Kidney Chemistry Blood flow Diet Sodium-Restricted Capillaries Peripheral Heat stress Endocrinology medicine.anatomical_structure Regional Blood Flow Blood Vessels Vascular Resistance medicine.symptom Vasoconstriction Papio |
| Zdroj: | Journal of Applied Physiology. 62:1538-1543 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/jappl.1987.62.4.1538 |
| Popis: | The cutaneous vasodilation and renal vasoconstriction in baboons during environmental heating (EH) appear to be produced predominantly by sympathetic vasoconstrictor withdrawal and activation of the renin-angiotensin system, respectively. Since these mechanisms may be influenced differently by sodium depletion, this study examined the hypothesis that sodium depletion would have a differential effect on cutaneous and renal vascular responses to EH. Sodium depletion was produced in chronically instrumented baboons by placing them on low-salt intake for 8–19 days along with diuretic administration. EH consisted of exposing the baboon to an ambient temperature of 40–42 degrees C until core temperature (Tc) reached 39.8–40.0 degrees C. Both control plasma renin activity (PRA) and the rise in PRA with Tc during EH were considerably larger in sodium-depleted baboons. However, the magnitudes of the progressive increases in iliac vascular conductance (used as an index of hindlimb cutaneous vasodilation) and renal vascular resistance with rising Tc during EH were unaltered by sodium depletion. Therefore, neither cutaneous nor renal vascular responses to EH are influenced by elevated PRA and other changes accompanying sodium depletion in the baboon. |
| Databáze: | OpenAIRE |
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