Associated conditions in patients with multiple dermatofibromas: Case reports and literature review
| Autor: | Philip R. Cohen, Ryan R Riahi, Stratton B Grisoli, Surget V Beatrous |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment Etravirine Dermatology 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Breast cancer Psoriasis medicine Optic neuritis Immunodeficiency business.industry Cancer Immunosuppression General Medicine medicine.disease 030104 developmental biology chemistry Dolutegravir Immunology angiohistiocytoma autoimmune benign fibrous histiocytoma breast cancer dermal dendrocytoma dermatofibroma fibroma simplex histiocytoma HIV immunodeficiency immunosuppression multiple nodular subepidermal fibrosis sclerosing hemangio business medicine.drug |
| Zdroj: | Beatrous, Surget V; Riahi, Ryan R; Grisoli, Stratton B; & Cohen, Philip R. (2017). Associated conditions in patients with multiple dermatofibromas: Case reports and literature review. Dermatology Online Journal, 23(9). Retrieved from: http://www.escholarship.org/uc/item/8zv852d8 |
| ISSN: | 1087-2108 |
| DOI: | 10.5070/d3239036479 |
| Popis: | Dermatofibromas are benign, fibrohistiocytic, dermal tumors. Solitary dermatofibromas may be incidental findings, whereas multiple dermatofibromas may be associated with systemic conditions or previous therapies. Two women and one man with multiple dermatofibromas and an associated systemic condition, immunosuppression, or both, are described. Nine dermatofibromas developed in a woman with hypothyroidism, optic neuritis, and Arnold Chiari I malformation. Five dermatofibromas developed in a woman with breast cancer who had received several systemic antineoplastic therapies. Eleven dermatofibromas developed in a man with HIV whose systemic therapies included acyclovir, darunavir/cobicistat, dolutegravir, etravirine, and ritonavir. Conditions associated with multiple dermatofibromas include autoimmune diseases, cancer, chromosomal abnormalities, immunodeficiencies, metabolic disturbances, and altered physiologic states such as pregnancy. Medications received by patients with multiple dermatofibromas included immunosuppressive agents, psoriasis therapies, and antineoplastic drugs. Multiple dermatofibromas can be observed in patients with associated medical conditions, systemic therapies, or both. Therefore, in individuals presenting with multiple dermatofibromas, not only evaluation for associated disorders, but also review of prior and current drug therapies, should be considered. |
| Databáze: | OpenAIRE |
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