An E7-based therapeutic vaccine protects mice against HPV16 associated cancer
| Autor: | Vadim Mett, Rosella Franconi, Francesca Paolini, Aldo Venuti, Vidadi Yusibov, Laura Dalla Vedova, Silvia Massa |
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| Rok vydání: | 2009 |
| Předmět: |
Papillomavirus E7 Proteins
medicine.medical_treatment Nicotiana benthamiana Mice Papillomavirus Vaccines Cancer immunotherapy Tobacco medicine Animals Vaccines Synthetic General Veterinary General Immunology and Microbiology biology Papillomavirus Infections Vaccination Public Health Environmental and Occupational Health Cancer Neoplasms Experimental Oncogene Proteins Viral Immunotherapy biology.organism_classification medicine.disease Mice Inbred C57BL Infectious Diseases Immunization Immunology Molecular Medicine Female Cancer vaccine Neoplasm Transplantation |
| Zdroj: | Vaccine. 27:3395-3397 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2009.01.068 |
| Popis: | Plant-derived vaccines represent an attractive strategy for cancer immunotherapy due to their relative safety and cost-effectiveness. We evaluated the anti-tumour activity of a Nicotiana benthamiana produced vaccine candidate based on the non-transforming E7 protein of HPV-16 fused to beta-1,3-1,4-glucanase of Clostridium thermocellum. Two doses of vaccine at two week intervals were administered to groups of C57BL/6 mice starting 3 or 6 days after challenge with tumourigenic E7-expressing TC-1* cells. Inhibition of tumour growth and increased survival was observed in both groups treated with vaccine. These data suggest the potential of plants as a platform for producing therapeutic vaccines. |
| Databáze: | OpenAIRE |
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