19. MALE BREAST CANCER: AETIOLOGY, GENETICS AND CLINICAL MANAGEMENT

Autor:	M D, Tischkowitz, S V, Hodgson, I S, Fentiman
Rok vydání:	2002
Předmět:	Male Risk Factors Genes BRCA2 Genes BRCA1 Humans Penetrance General Medicine Prognosis Breast Neoplasms Male
Zdroj:	International Journal of Clinical Practice. 56:750-754
ISSN:	1742-1241 1368-5031
DOI:	10.1111/j.1742-1241.2002.tb11371.x
Popis:	Male breast cancer (MBC) is a rare disease with an older average age of presentation than in women. Predisposing factors include increased exposure to oestrogen and being a carrier of a BRCA2 mutation. Most MBC is ductal and the majority are oestrogen receptor positive. Modified radical mastectomy is the treatment of choice for local disease and adjuvant radio-, hormonal and chemotherapy should all be considered. Stage for stage, the prognosis for MBC is similar to that for female breast cancer. Despite a wealth of small retrospective studies on MBC, its rarity means there is a lack of prospective randomised controlled treatment trials, which needs to be addressed if significant advances are to be made in the treatment of this unusual and challenging disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d7606d1ec6486a6ec1e9092059bc60 https://doi.org/10.1111/j.1742-1241.2002.tb11371.x Zobrazit plný text záznamu