Circulating resistin concentrations are independently associated with aortic pulse wave velocity in a community sample
| Autor: | Pinhas Sareli, Glenda Norman, Olebogeng H.I. Majane, Frédéric Michel, Angela J. Woodiwiss, Monica Gomes, Aletta M.E. Millen, Gavin R. Norton |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology Black People Adipokine Pulse Wave Analysis 030204 cardiovascular system & hematology Body Mass Index South Africa Young Adult 03 medical and health sciences Vascular Stiffness 0302 clinical medicine Insulin resistance Internal medicine medicine.artery Internal Medicine medicine Humans Arterial Pressure Resistin Obesity 030212 general & internal medicine Pulse wave velocity Aorta Adiponectin business.industry nutritional and metabolic diseases Middle Aged medicine.disease C-Reactive Protein Blood pressure Endocrinology Hypertension cardiovascular system Female Aortic stiffness Insulin Resistance Waist Circumference Cardiology and Cardiovascular Medicine business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Hypertension. 34:274-281 |
| ISSN: | 0263-6352 |
| Popis: | AIMS The role of the adipokine, resistin in mediating increases in aortic stiffness is uncertain. We aimed to determine independent relations between circulating resistin concentrations and aortic pulse wave velocity (PWV) and wave reflection in a community-based sample with a high prevalence of untreated hypertension and obesity. METHODS Plasma resistin, adiponectin, and C-reactive protein concentrations (ELISA); carotid-femoral (aortic) PWV and the aortic reflected wave index (applanation tonometry and SphygmoCor software) were determined in 683 randomly selected participants of African ancestry from SOWETO, South Africa who had never received antihypertensive therapy. RESULTS Resistin concentrations were not independently associated with office or 24-h (n = 492) blood pressure (BP). In a stepwise regression model with BMI included in the model, age (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|