Mitochondrial DNA copy number in colorectal cancer: between tissue comparisons, clinicopathological characteristics and survival
| Autor: | Leo J. Schouten, Marjolein H.F.M. Lentjes, Hubert J.M. Smeets, Matty P. Weijenberg, Piet A. van den Brandt, Colinda C. J. M. Simons, Ralph W.H. Gottschalk, A.M. Voets, Manon van Engeland, Frits H.M. van Osch |
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| Přispěvatelé: | Complexe Genetica, Genetica & Celbiologie, Epidemiologie, Gezondheidsrisico Analyse en Toxicologie, Pathologie, Klinische Genetica, RS: CAPHRI School for Public Health and Primary Care, RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation, RS: CAPHRI - R5 - Optimising Patient Care, RS: GROW - Oncology, Psychiatrie & Neuropsychologie, RS: GROW - R1 - Prevention, RS: GROW - R2 - Basic and Translational Cancer Biology, RS: GROW - R4 - Reproductive and Perinatal Medicine, RS: FHML MaCSBio |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Oncology
Adenoma Male Cancer Research medicine.medical_specialty Pathology DNA Copy Number Variations Colorectal cancer MICROSATELLITE INSTABILITY Population Gene Dosage PROGRESSION Kaplan-Meier Estimate Biology METABOLISM medicine.disease_cause DNA Mitochondrial SEQUENCE PATHWAY BRAF MUTATION Internal medicine MTDNA medicine Carcinoma KRAS Humans Prospective Studies Prospective cohort study education neoplasms Aged Proportional Hazards Models education.field_of_study Cancer Microsatellite instability General Medicine Middle Aged medicine.disease GENE digestive system diseases CELLS Female Colorectal Neoplasms |
| Zdroj: | Carcinogenesis, 36(12), 1502-1510. Oxford University Press |
| ISSN: | 1460-2180 0143-3334 |
| Popis: | Low mitochondrial DNA (mtDNA) copy number in tumors has been associated with worse prognosis in colorectal cancer (CRC). This study further deciphers the role of mtDNA copy number in CRC by comparing mtDNA copy number between healthy, adenoma and carcinoma tissue, by investigating its association according to several clinicopathological characteristics in CRC, and by relating it to CRC-specific survival in CRC patients. A hospital-based series of samples including cancer, adenoma and adjacent histologically normal tissue from primary CRC patients (n = 56) and recurrent CRC (n = 16) was studied as well as colon mucosa samples from healthy subjects (n = 76). Furthermore, mtDNA copy number was assessed in carcinomas of 693 CRC cases identified from the population-based Netherlands Cohort Study (NLCS). MtDNA copy number was significantly lower in carcinoma tissue (P = 0.011) and adjacent tissue (P |
| Databáze: | OpenAIRE |
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