Suppression of leukotriene B4 production is involved in the anti-pruritic action of Grifola frondosa in pollen allergy-induced ocular itching in mice
| Autor: | Koichiro Mori, Tsugunobu Andoh, Junya Kawai |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Leukotriene B4
Agriculture (General) Immunology mast cells leukotriene b4 Biology Pollen Allergy 01 natural sciences S1-972 chemistry.chemical_compound 0404 agricultural biotechnology pollen allergy otorhinolaryngologic diseases medicine itch Health food Grifola frondosa grifola frondosa Ergosterol ergosterol Traditional medicine 010401 analytical chemistry 04 agricultural and veterinary sciences RC581-607 040401 food science 0104 chemical sciences Edible mushroom chemistry Itching Immunologic diseases. Allergy medicine.symptom Agronomy and Crop Science Food Science |
| Zdroj: | Food and Agricultural Immunology, Vol 32, Iss 1, Pp 310-320 (2021) |
| ISSN: | 1465-3443 0954-0105 |
| Popis: | Grifola frondosa (G. frondosa) is an edible mushroom consumed as a health food in Asia that has recently been reported to have anti-allergic effects. In this study, we investigated the effects of G. frondosa on pollen allergy-induced ocular itching in mice. G. frondosa was boiled and freeze-dried (heat-treated G. frondosa). Oral administration of heat-treated G. frondosa (0.1 and 1 g/kg) suppressed pollen allergy-induced ocular itching and plasma extravasation but not histamine-induced plasma extravasation. Oral administration of ergosterol, an active ingredient in G. frondosa (5 and 50 mg/kg), or zileuton (100 mg/kg), which is an inhibitor of 5-lipoxygenase (the main enzyme required for leukotriene B4 production), inhibited pollen allergy-induced ocular itching. In addition, ergosterol inhibited antigen-induced leukotriene B4 production in mast cells. These findings suggest that G. frondosa and its active ingredient ergosterol prevent pollen allergy-induced itching through the inhibition of leukotriene B4 production in mast cells. |
| Databáze: | OpenAIRE |
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