Current management and prognostic features for gastrointestinal stromal tumor (GIST)
| Autor: | Samir Ambrale, Gurpreet Lamba, Byung Lee, Delong Liu, Ridhi Gupta |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Pathology Stromal cell Hematology GiST business.industry lcsh:RC633-647.5 medicine.medical_treatment Review lcsh:Diseases of the blood and blood-forming organs lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens lcsh:RC254-282 digestive system diseases Targeted therapy Internal medicine Epidemiology medicine Adjuvant therapy Stromal tumor Stage (cooking) business |
| Zdroj: | Experimental Hematology & Oncology, Vol 1, Iss 1, p 14 (2012) Experimental Hematology & Oncology |
| ISSN: | 2162-3619 |
| DOI: | 10.1186/2162-3619-1-14 |
| Popis: | Stromal or mesenchymal neoplasms affecting the gastrointestinal (GI) tract have undergone a remarkable evolution in how they are perceived, classified, approached, diagnosed and managed over the last 30 years. Gastrointestinal stromal tumors (GIST) account for approximately 1% to 3% of all malignant GI tumors. The clinical features can vary depending on the anatomic location, size and aggressiveness of the tumor. Metastatic GIST represents a successful example of molecular targeted therapy. In this comprehensive review, we discuss the epidemiology, clinical features and diagnostic modalities for GIST. We also describe treatment options for early stage, locally advanced and metastatic GIST. Indications for neoadjuvant and adjuvant therapy along with duration of therapy are also explained. A brief discussion of latest biomarkers and updates from recent meetings is also provided. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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