Role of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in Peyronie's disease: a new diagnostic approach to predict the stage of the disease?
| Autor: | José Medina Polo, Manuel Alonso Isa, Alfredo Rodríguez Antolín, Esther García Rojo, Celeste Manfredi, Rocío Santos-Pérez de la Blanca, Javier Romero Otero, Borja García Gómez |
|---|---|
| Přispěvatelé: | Rojo, Eg, Gomez, Bg, de la Blanca, Rsp, Manfredi, C, Isa, Ma, Polo, Jm, Antolin, Ar, Otero, Jr |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Wilcoxon signed-rank test Neutrophils diagnosis Peyronie's disease Urology Penile Induration Physical examination Disease Gastroenterology Leukocyte Count neutrophil-to-lymphocyte ratio Internal medicine medicine Humans Cutoff Lymphocytes Stage (cooking) Neutrophil to lymphocyte ratio Retrospective Studies Receiver operating characteristic medicine.diagnostic_test business.industry inflammation peyronie's disease platelet-to-lymphocyte ratio General Medicine Middle Aged Prognosis medicine.disease Diseases of the genitourinary system. Urology Original Article RC870-923 business Biomarkers |
| Zdroj: | Asian Journal of Andrology Asian Journal of Andrology, Vol 23, Iss 3, Pp 325-329 (2021) |
| ISSN: | 1008-682X |
| DOI: | 10.4103/aja.aja_74_20 |
| Popis: | Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been associated with multiple entities and several types of cancers. They can be assumed as markers of inflammatory imbalance. The objective of this study is to evaluate the NLR and PLR in Peyronie's disease (PD) and to establish a comparison of its values in the acute and chronic stages. We recruited patients with PD from March 2018 to March 2019. The patients enrolled underwent medical and sexual history as well as a physical examination. The values of blood count of each patient were collected both in the acute and chronic stages. Wilcoxon test was used to compare the acute and chronic stage ratios. Kruskal-Wallis test was carried out to evaluate the impact of treatments on the ratios. To identify cutoff values, we used sensibility and specificity tables and receiver operating characteristic (ROC) curves. A total of 120 patients were enrolled. Their mean age was 55.85 (range: 18-77) years and the mean penile curvature was 48.43 degrees (range: 10 degrees-100 degrees). In the acute stage, the mean NLR was 2.35 and the mean PLR was 111.22. These ratios, in the chronic stage, were 1.57 and 100.00, respectively. Statistically significant differences between acute and stable stages for both indices were found (NLR: P< 0.0001; PLR: P= 0.0202). The optimal cutoff for classification in acute or stable stage was 2 for NLR and 102 for PLR. According to our results, with an ordinary blood count, we could have important indications regarding the disease stage of the patient, and consequently on the most appropriate type of therapy to choose. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|