Fetal Growth, Cognitive Function, and Brain Volumes in Childhood and Adolescence
| Autor: | Tormod Rogne, Heidi Furre Østgård, Andreas Aass Engstrøm, Geir Jacobsen, Marit Martinussen, Jon Skranes |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Pediatrics medicine.medical_specialty Adolescent Young Adult Child Development Cognition Pregnancy medicine Fetal growth Humans Prospective Studies Young adult Child Prospective cohort study reproductive and urinary physiology Fetal Growth Retardation business.industry Case-control study Brain Obstetrics and Gynecology Organ Size medicine.disease Child development Multicenter study Case-Control Studies Child Preschool Infant Small for Gestational Age Female business |
| Zdroj: | Obstetrics & Gynecology. 125:673-682 |
| ISSN: | 0029-7844 |
| DOI: | 10.1097/aog.0000000000000694 |
| Popis: | To evaluate the association between fetal growth pattern and cognitive function at 5 and 9 years and regional brain volumes at 15 years.Eighty-three term-born small-for-gestational-age (SGA) neonates and 105 non-SGA neonates in a control group were available for follow-up. Based on serial fetal ultrasound measurements from gestational weeks 25-37, SGA neonates were classified with fetal growth restriction (n=13) or non-fetal growth restriction (n=36). Cognitive function was assessed at 5 and 9 years, and brain volumes were estimated with cerebral magnetic resonance imaging at 15 years.Small-for-gestational-age children had lower performance intelligence quotient at 5 years compared with those in a control group (107.3 compared with 112.5, P.05). Although there were no differences between the SGA non-fetal growth restriction and control groups, the SGA fetal growth restriction group had significantly lower performance intelligence quotient at 5 years (103.5 compared with 112.5, P.05) and 9 years (96.2 compared with 107.5, P.05) compared with those in the control group. There were some brain volume differences at 15 years between SGA children and those in the control group, but after adjustment for total intracranial volume, age at examination, and sex, there were only significant differences between the SGA fetal growth restriction and control groups for thalamic (17.4 compared with 18.6 cm, P.01) and cerebellar white matter volumes (21.5 compared with 24.3 cm, P.01).Small-for-gestational-age children had lower intelligence quotient scores at 5 and 9 years and smaller brain volumes at 15 years compared with those in the control group, but these findings were only found in those with fetal growth restriction, indicating a possible relationship to decelerated fetal growth.II. |
| Databáze: | OpenAIRE |
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