The Effects of Fish Oil Supplementation in Pregnancy on Breast Milk Fatty Acid Composition Over the Course of Lactation: A Randomized Controlled Trial

Autor: Glenys Dixon, Leon R. Mitoulas, Karen Simmer, Janet Dunstan, Susan L. Prescott, Dorota A. Doherty, Peter E. Hartmann
Rok vydání: 2007
Předmět:
Adult
medicine.medical_specialty
Time Factors
Docosahexaenoic Acids
Cephalometry
Gestational Age
Breast milk
Double-Blind Method
Pregnancy
Internal medicine
Lactation
Humans
Plant Oils
Medicine
Longitudinal Studies
Infant Nutritional Physiological Phenomena
Olive Oil
Prenatal Nutritional Physiological Phenomena
Unsaturated fatty acid
chemistry.chemical_classification
Milk
Human
Verbal Behavior
business.industry
Body Weight
Erythrocyte Membrane
Infant
food and beverages
Fish oil
Eicosapentaenoic acid
Body Height
Breast Feeding
Endocrinology
medicine.anatomical_structure
Eicosapentaenoic Acid
chemistry
Docosahexaenoic acid
Dietary Supplements
Pediatrics
Perinatology and Child Health
Female
lipids (amino acids
peptides
and proteins)
business
Head
Breast feeding
Psychomotor Performance
Polyunsaturated fatty acid
Zdroj: ResearcherID
ISSN: 1530-0447
0031-3998
DOI: 10.1203/pdr.0b013e318159a93a
Popis: This study evaluated the longitudinal effect of fish oil in pregnancy on breast milk fatty acid composition and infant outcomes. In a randomized, controlled trial, 98 women received 2.2 g docosahexaenoic acid (DHA) and 1.1 g eicosapentaenoic acid (EPA) or olive oil from 20 wk of gestation until delivery. Fatty acid composition in breast milk (at 3 d, 6 wk, and 6 mo) and infant erythrocyte membranes (at 1 y) were determined by gas liquid chromatography. Breast milk fatty acids were examined in relationship to growth and development. Compared with control group, breast milk from women who received fish oil had proportionally higher DHA and EPA levels at 3 d and 6 wk after delivery, but this difference was no longer apparent by 6 mo. Infant DHA status at 1 y of age was directly related to DHA levels at 3 d, 6 wk, and 6 mo postpartum (but not to antenatal supplementation). Both EPA and DHA in breast milk were positively correlated with Griffith's developmental scores including hand and eye coordination. Thus, supplementation in pregnancy was associated with increased n-3 long-chain polyunsaturated fatty acids (LCPUFAs) in breast milk, particularly in early lactation, and this was positively associated with infant DHA status at 1 y.
Databáze: OpenAIRE
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