Fertility-sparing surgery for patients with malignant ovarian germ cell tumors: 10 years of clinical experience from a tertiary referral center
| Autor: | Mislav Mikuš, Velena Radošević, Mario Ćorić, Pavao Planinić, Goran Vujić, Nikolina Benco, Tomislav Puževski, Helena Lovrić, Luka Matak, Mirna Bajt |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_treatment
Tertiary Care Centers 0302 clinical medicine Obstetrics and gynaecology Pregnancy Laparotomy Medicine Laparoscopy Ovarian Neoplasms / drug therapy Ovarian Neoplasms 030219 obstetrics & reproductive medicine medicine.diagnostic_test Teratoma Obstetrics and Gynecology Teratoma / pathology Fertility Preservation Neoplasms Germ Cell and Embryonal / pathology General Medicine Middle Aged Neoplasms Germ Cell and Embryonal Neoplasms Germ Cell and Embryonal / drug therapy Omentum / surgery Chemotherapy Adjuvant 030220 oncology & carcinogenesis Ovarian Neoplasms / surgery Female medicine.symptom Chemotherapy Adjuvant / adverse effects Adjuvant chemotherapy Fertility-sparing surgery Malignant ovarian germ cell tumors Reproductive outcome Omentum Ovariectomy / methods Adult medicine.medical_specialty Adolescent Croatia Ovariectomy Ovarian Neoplasms / pathology 03 medical and health sciences Young Adult Humans Neoplasm Staging Retrospective Studies Chemotherapy business.industry Neoplasm Recurrence Local / pathology Abdominal distension medicine.disease Surgery Fertility Neoplasms Germ Cell and Embryonal / surgery Lymph Node Excision Immature teratoma Lymphadenectomy Germ cell tumors Neoplasm Recurrence Local business |
| Popis: | Purpose: To describe a case series of patients with malignant ovarian germ cell tumors (MOGCT) treated exclusively with fertility-sparing surgery (FSS) with or without adjuvant chemotherapy. ----- Methods: We retrospectively reviewed the records of 27 patients with MOGCT treated in the Department of Obstetrics and Gynecology, University Hospital Center Zagreb, Croatia, between January 2009 and July 2019. ----- Results: The median age at diagnosis was 22 years, and the main symptom was abdominal distension (57.0%). The most prevalent histological subtype was immature teratoma (n = 13, 48.1%). Twenty-three patients (85.2%) had laparotomy and 4 (14.8%) had laparoscopy, without conversions. Lymphadenectomy was performed in 16 (59.3%) patients, with 184 removed lymph nodes, and omentectomy was performed in 19 (70.4%) patients. The rate of chemotherapy administration was 81.5%. The follow-up length ranged between 6.30 and 115.1 months (median: 49.60 months). No patient experienced tumor recurrence. The rate of complete gross resection was 100%. At the time of analysis, all patients were alive and disease free. Fifty percent of patients who actively tried to conceive after FSS became pregnant, with 12 deliveries. ----- Conclusion: This study suggests that FSS is a safe treatment option for MOGCT, regardless of tumor stage and histological type. |
| Databáze: | OpenAIRE |
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