Response of Staphylococcus aureus to Salicylate Challenge
Autor: | Brian J. Wilkinson, John E. Gustafson, Christopher T. Price, Wayne A. Van Voorhies, Arunachalam Muthaiyan, James E. Graham, James T. Riordan |
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Rok vydání: | 2007 |
Předmět: |
Staphylococcus aureus
Formates Genomics and Proteomics medicine.drug_class Antibiotics Repressor Biology medicine.disease_cause Gluconates Microbiology Transcriptome Antibiotic resistance Anti-Infective Agents Bacterial Proteins Drug Resistance Multiple Bacterial medicine RNA Messenger Molecular Biology Gene Gluconeogenesis Gene Expression Regulation Bacterial Microarray Analysis Antimicrobial Salicylates RNA Bacterial Efflux Glycolysis |
Zdroj: | Journal of Bacteriology. 189:220-227 |
ISSN: | 1098-5530 0021-9193 |
Popis: | Growth of Staphylococcus aureus with the nonsteroidal anti-inflammatory salicylate reduces susceptibility of the organism to multiple antimicrobials. Transcriptome analysis revealed that growth of S. aureus with salicylate leads to the induction of genes involved with gluconate and formate metabolism and represses genes required for gluconeogenesis and glycolysis. In addition, salicylate induction upregulates two antibiotic target genes and downregulates a multidrug efflux pump gene repressor ( mgrA ) and sarR , which represses a gene ( sarA ) important for intrinsic antimicrobial resistance. We hypothesize that these salicylate-induced alterations jointly represent a unique mechanism that allows S. aureus to resist antimicrobial stress and toxicity. |
Databáze: | OpenAIRE |
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