Protective effect of grape seed extract against ischaemia/reperfusion injury in a rat epigastricflap model
| Autor: | Yigit Ozer Tiftikcioglu, M Berktas, G. Meltem Karaaslan, Duygu Kankaya, Uğur Koçer, Yüksel Kankaya, M. Gürhan Ulusoy, Onder Karaaslan, Serdar Tuncer |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Necrosis food.ingredient Ischaemia-reperfusion injury Ischemia Neovascularization Physiologic Antioxidants Surgical Flaps Neovascularization food Fibrosis medicine Animals Proanthocyanidins Rats Wistar Grape Seed Extract business.industry Graft Survival Skin Transplantation medicine.disease Surgery Rats Disease Models Animal Treatment Outcome Proanthocyanidin Grape seed extract Reperfusion Injury Grape seed proanthocyanidin medicine.symptom business Follow-Up Studies |
| Zdroj: | Journal of plastic, reconstructiveaesthetic surgery : JPRAS. 63(4) |
| ISSN: | 1878-0539 |
| Popis: | Proanthocyanidins are potent natural antioxidants which belong to a class of polyphenols. Proanthocyanidin-rich extracts are prepared from grape seeds. The effect of grape seed proanthocyanidin extract (GSPE) on the viability of abdominal skin flaps exposed to warm ischaemia and subsequent reperfusion were studied in 40 male Wistar rats. In the control group (group I; n=20), rats were fed with standard, non-purified rat diet, and the study group received GSPE 100 mgkg(-1) per day 1 week prior to surgery and 1 week following surgery. Abdominal island flaps were elevated in both the groups and subjected to 8h of warm ischaemia, followed by reperfusion. Mean flap survival areas in groups I (control group) and II (treatment group) were calculated to be 58.3%+/-11.72 and 81.0%+/-11.88, respectively. Flap survival on day 7 was significantly higher in group II compared to group I (p |
| Databáze: | OpenAIRE |
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