Expression and immunohistochemical detection of nesfatin-1 in the gastrointestinal tract of Casertana pig
| Autor: | L. Maruccio, Finizia Russo, M. G. Russolillo, Vittoria Lombardi, Marina Paolucci, Ettore Varricchio |
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| Přispěvatelé: | Ettore, Varricchio, Maria Grazia, Russolillo, Finizia, Russo, Vittoria, Lombardi, Marina, Paolucci, Maruccio, Lucianna |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Pathology Histology Swine Rectum Enteroendocrine cell Nerve Tissue Proteins Biology Energy homeostasis Ileocecal valve Eating Western blot Internal medicine medicine media_common.cataloged_instance Animals Nucleobindins Casertana pig media_common Neurons Gastrointestinal tract medicine.diagnostic_test Calcium-Binding Proteins Cell Biology General Medicine Immunohistochemistry DNA-Binding Proteins Gastrointestinal Tract Endocrinology medicine.anatomical_structure |
| Zdroj: | Acta histochemica. 116(4) |
| ISSN: | 1618-0372 |
| Popis: | In this study, we report nesfatin-1 immunoreactivity in the gastrointestinal tract of Casertana breed pig. The newly discovered anorexigenic peptide nesfatin-1 has been shown to possess physiological relevance in regulating food intake and energy homeostasis at a central level, although evidence has been accumulating that it may also play important functions at a more local gastroenteric level. Nesfatin-1 immunoreactive endocrine cells have been detected in the gastric fundus and ileocecal valve. Nesfatin-1 immunopositive neurons and nerve fibers have been observed mainly in the enteric plexuses. Western blot analysis confirmed the immunohistochemical observations, showing immunoreactive bands in all analyzed gastrointestinal tracts with the exception of the rectum. Nesfatin-1 immunodetection in the swine digestive system reinforces the importance of the role played by nesfatin-1 at the gastrointestinal level and sustains the necessity to study the role of this peptide in the regulation of food intake in farm species for which weight gain is essential for optimizing production. |
| Databáze: | OpenAIRE |
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