Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid
| Autor: | Göran Engberg, Kaj Blennow, Maria Bhat, Mikael Landén, Sophie Erhardt, Henrik Zetterberg, Lilly Schwieler, Viktoria Johansson, Lennart Wetterberg, Tyrone D. Cannon, Magdalena E. Kegel, Christina M. Hultman |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Kynurenine pathway Short Communication Chemokine ligand 2 Kynurenic Acid Psykiatri Cohort Studies 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Kynurenic acid Cerebrospinal fluid Internal medicine medicine Humans Pharmacology (medical) Chemokine CCL2 Biological Psychiatry Aged Sweden Psychiatry Monocyte Tryptophan Neurosciences Twin study General Medicine Biomarker Middle Aged Quinolinic Acid medicine.disease 030227 psychiatry Monocyte chemoattractant protein-1 Psychiatry and Mental health medicine.anatomical_structure Endocrinology chemistry Schizophrenia Female 030217 neurology & neurosurgery Kynurenine Neurovetenskaper Quinolinic acid |
| Zdroj: | European Archives of Psychiatry and Clinical Neuroscience |
| Popis: | Preclinical studies indicate a link between the kynurenine pathway and monocyte chemoattractant protein-1 (MCP-1), but there is a lack of clinical studies examining this further. We here perform a secondary analysis of kynurenine metabolites and MCP-1 in cerebrospinal fluid of 23 twins affected from schizophrenia, bipolar disorder or unaffected. We show an association between MCP-1 and kynurenic acid (KYNA), driven by unique environmental influences and a less pronounced association between MCP-1 and tryptophan. No association was detected between MCP-1 and quinolinic acid. Further studies on the mechanism behind the putative relationship between KYNA and MCP-1 are needed. Electronic supplementary material The online version of this article (10.1007/s00406-019-01042-9) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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