Bioavailability and chemotherapeutic activity of clofazimine against Mycobacterium avium complex infections in beige mice following a single implant of a biodegradable polymer
| Autor: | Pattisapu R. J. Gangadharam, Donald L. Wise, Subramanian Kailasam |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Microbiology (medical) Polymers Biological Availability Biology Clofazimine Microbiology Mycobacterium tuberculosis Mice Polylactic Acid-Polyglycolic Acid Copolymer Pharmacokinetics Oral administration medicine Animals Pharmacology (medical) Lactic Acid Mycobacterium leprae Mycobacterium avium-intracellulare Infection Antibacterial agent Drug Implants Pharmacology biology.organism_classification Bioavailability Mice Inbred C57BL Infectious Diseases Liver Implant Polyglycolic Acid medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 33:273-279 |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/33.2.273 |
| Popis: | We have studied the bioavailability of clofazimine following administration of a single dose of the drug in the biodegradable polymer polylactic-co-glycolic acid (PLGA). We compared the levels of clofazimine achieved in the liver with single implants with those obtained with daily oral treatment. Even though the levels achieved with implants were much lower than those obtained after daily oral treatment, they were higher than the MIC of clofazimine for Mycobacterium leprae, Mycobacterium tuberculosis and Mycobacterium avium complex (MAC). Experimental studies in beige mice after infection with MAC strain 101 showed similar reductions in cfu counts, after both single dose polymer and daily oral treatment. Macroscopically, hyperpigmentation giving an orange-yellow colour to all visceral organs, was seen in animals after daily oral treatment but not in those animals that received polymer implants. |
| Databáze: | OpenAIRE |
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