A Closed-Loop Optogenetic Stimulation Device
| Autor: | Abbas Z. Kouzani, Epsy S. Edward |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
closed-loop control
Deep brain stimulation Rodent Computer Networks and Communications Computer science medicine.medical_treatment 0206 medical engineering lcsh:TK7800-8360 Stimulation 02 engineering and technology Optogenetics 03 medical and health sciences 0302 clinical medicine biology.animal medicine Electrical and Electronic Engineering biology business.industry lcsh:Electronics optogenetic stimulator 020601 biomedical engineering Power (physics) deep brain stimulation Hardware and Architecture Control and Systems Engineering action potential detector Optical stimulation Signal Processing hybrid electrode business Closed loop 030217 neurology & neurosurgery Computer hardware |
| Zdroj: | Electronics, Vol 9, Iss 1, p 96 (2020) Electronics Volume 9 Issue 1 |
| ISSN: | 2079-9292 |
| Popis: | Closed-loop optogenetic stimulation devices deliver optical stimulations based on real-time measurement and analysis of neural responses to stimulations. However, the use of large bench-top and tethered devices hinders the naturalistic test environment, which is crucial in pre-clinical neuroscience studies involving small rodent subjects. This paper presents a tetherless, lightweight and miniaturized head-mountable closed-loop optogenetic stimulation device. The device consists of three hardware modules: a hybrid electrode, an action potential detector, and an optogenetic stimulator. In addition, the device includes three software modules: a feature extractor, a control algorithm, and a pulse generator. The details of the design, implementation, and bench-testing of the device are presented. Furthermore, an in vitro test environment is formed using synthetic neural signals, wherein the device is validated for its closed-loop performance. During the in vitro validation, the device was able to identify abnormal neural signals, and trigger optical stimulation. On the other hand, it was able to also distinguish normal neural signals and inhibit optical stimulation. The overall power consumption of the device is 24 mW. The device measures 6 mm in radius and weighs 0.44 g excluding the power source. |
| Databáze: | OpenAIRE |
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