Activation and manipulation of inflammasomes and pyroptosis during bacterial infections

Autor:	Elliott M. Bernard, Petr Broz
Rok vydání:	2022
Předmět:	Cell Death Inflammasomes Apoptosis Bacterial Infections Humans Inflammasomes/metabolism Pyroptosis bacterial infections inflammasomes pyroptosis Cell Biology Molecular Biology Biochemistry
Zdroj:	The Biochemical journal, vol. 479, no. 7, pp. 867-882
ISSN:	1470-8728 0264-6021
DOI:	10.1042/bcj20220051
Popis:	Following detection of pathogen infection and disrupted cellular homeostasis, cells can activate a range of cell death pathways, such as apoptosis, necroptosis and pyroptosis, as part of their defence strategy. The initiation of pro-inflammatory, lytic pyroptosis is controlled by inflammasomes, which respond to a range of cellular perturbations. As is true for many host defence pathways, pathogens have evolved multiple mechanisms to subvert this pathway, many of which have only recently been described. Herein, we will discuss the mechanisms by which inflammasomes sense pathogen invasion and initiate pyroptosis and the effector mechanisms used by pathogens to suppress this pathway and preserve their niche.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c38416d3ad5e74cf3e2581f530a06c https://doi.org/10.1042/bcj20220051 Zobrazit plný text záznamu