Usefulness of presepsin / creatinine ratio as a new index that corrects for renal function
| Autor: | Kojiro Nagai, Mai Nishioka, Masashi Miyoshi, Tetsuji Takayama, Yusuke Inoue, Takayuki Nakao, Akishige Ikegame |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Lipopolysaccharide Receptors Urology Renal function Reference range Kidney urologic and male genital diseases behavioral disciplines and activities General Biochemistry Genetics and Molecular Biology Sepsis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Healthy volunteers Humans Medicine In patient Renal Insufficiency Chronic Stage (cooking) Creatinine business.industry musculoskeletal neural and ocular physiology General Medicine medicine.disease Peptide Fragments body regions 030228 respiratory system chemistry 030220 oncology & carcinogenesis population characteristics business Biomarkers Glomerular Filtration Rate Kidney disease |
| Zdroj: | The Journal of Medical Investigation. 68:105-111 |
| ISSN: | 1349-6867 1343-1420 |
| DOI: | 10.2152/jmi.68.105 |
| Popis: | Background : Presepsin (P-SEP) is a highly specific sepsis marker, and its fluctuation with respect to advanced renal impairment or sample agitation has not been fully investigated. We evaluated several renal function-corrected P-SEP indices to establish a simple index and its reference range. Methods : Blood samples for P-SEP measurement were collected with minimal agitation. P-SEP levels were measured using the rapid automated immunoanalyzer "PATHFAST." This study included 85 chronic kidney disease (CKD) patients, 65 healthy volunteers, and 4 sepsis patients. Results : Patients stratified by estimated glomerular filtration rate (GFR) had significantly higher P-SEP levels for CKD stage G3, especially the advanced GFR stage. We evaluated presepsin / creatinine (P-SEP / CRE) and P-SEP / eGFR ratios as possible indices for renal function. The P-SEP / CRE ratio exhibited no increase correlating with the GFR stage and was identical in the normal and CKD groups ; P-SEP / eGFR decreased if GFR stage worsened. The P-SEP / CRE ratio became significantly higher in sepsis patients and was a more useful index with a reference range of 67-263. Conclusions : P-SEP levels were inversely correlated with renal function, indicating the necessity to consider the influence of renal impairment in CKD patients. The P-SEP / CRE ratio is helpful for sepsis diagnosis, even in patients with renal impairment. J. Med. Invest. 68 : 105-111, February, 2021. |
| Databáze: | OpenAIRE |
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