Continuous Twin Screw Granulation: A Review of Recent Progress and Opportunities in Formulation and Equipment Design
| Autor: | Chris Vervaet, Christoph Portier, Valérie Vanhoorne |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
DELTA-MANNITOL
IMPACT Process development High Shear Granulation review Pharmaceutical Science CRITICAL QUALITY ATTRIBUTES 02 engineering and technology Review WET GRANULATION HIGH-SHEAR GRANULATION FOAM GRANULATION 030226 pharmacology & pharmacy Unmet needs 03 medical and health sciences Granulation 0302 clinical medicine Pharmacy and materia medica Medicine and Health Sciences continuous manufacturing Fluid Bed Granulation ORAL DOSAGE FORMS ACTIVE PHARMACEUTICAL INGREDIENT formulation development Continuous manufacturing 021001 nanoscience & nanotechnology Manufacturing engineering innovation process development RS1-441 Chemistry MICROCRYSTALLINE CELLULOSE twin screw granulation PROCESS PARAMETERS 0210 nano-technology Critical quality attributes General validity wet granulation |
| Zdroj: | Pharmaceutics Pharmaceutics, Vol 13, Iss 668, p 668 (2021) PHARMACEUTICS |
| ISSN: | 1999-4923 |
| Popis: | Continuous twin screw wet granulation is one of the key continuous manufacturing technologies that have gained significant interest in the pharmaceutical industry as well as in academia over the last ten years. Given its considerable advantages compared to wet granulation techniques operated in batch mode such as high shear granulation and fluid bed granulation, several equipment manufacturers have designed their own manufacturing setup. This has led to a steep increase in the research output in this field. However, most studies still focused on a single (often placebo) formulation, hence making it difficult to assess the general validity of the obtained results. Therefore, current review provides an overview of recent progress in the field of continuous twin screw wet granulation, with special focus on the importance of the formulation aspect and raw material properties. It gives practical guidance for novel and more experienced users of this technique and highlights some of the unmet needs that require further research. |
| Databáze: | OpenAIRE |
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