Intravenous Lipid Emulsion Therapy for Bromethalin Toxicity in a Dog
| Autor: | Brittany Heggem-Perry, Clara E Moran, Maureen McMichael, Mauria O'Brien |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Fat Emulsions
Intravenous Intravenous lipid emulsion 040301 veterinary sciences medicine.drug_class medicine.medical_treatment Metabolite Pharmacology 0403 veterinary science Toxicology 03 medical and health sciences chemistry.chemical_compound Dogs 0302 clinical medicine medicine Animals Ingestion Rodenticide Dog Diseases Small Animals Antidote Aniline Compounds business.industry Anticoagulant Rodenticides 030208 emergency & critical care medicine 04 agricultural and veterinary sciences Bromethalin Treatment Outcome chemistry Toxicity Female business |
| Zdroj: | Journal of the American Animal Hospital Association. 52:265-268 |
| ISSN: | 1547-3317 0587-2871 |
| DOI: | 10.5326/jaaha-ms-6396 |
| Popis: | Bromethalin is a central nervous system toxin currently incorporated into several different rodenticides. In 2008, the EPA requested that manufacturers phase out second-generation anticoagulant rodenticides. In response, manufacturers began to increase production of bromethalin-based rodenticides. It is likely that pet exposure to bromethalin will increase in the future. Bromethalin has no known antidote and tends to deposit in fat. Intravenous lipid emulsions (ILEs) are being used with increasing frequency in both human and veterinary medicine to treat numerous acute systemic toxicities. A 4 yr old spayed female Pit bull terrier was presented following witnessed ingestion of bromethalin rodenticide by the owners. Decontamination was unsuccessful and ILE was started. Serum was frozen at −80°C before and 1 hr after completion of ILE. In rats, the half-life of desmethylbromethalin, the toxic metabolite, has been reported at 5.6 days and 6 days, and it is likely to be similar in dogs. The only intervention between the pre-lipid serum sample and the post-lipid serum sample was the administration of ILE, and the serum desmethylbromethalin levels were reduced by 75% (from 4 ppb to 1 ppb) during this time. To the authors' knowledge, this is the first report describing treatment of bromethalin ingestion with ILE. |
| Databáze: | OpenAIRE |
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