Chitosan–magnesium aluminum silicate nanocomposite films: Physicochemical characterization and drug permeability

Autor: Thomas Rades, Thaned Pongjanyakul, Satit Puttipipatkhachorn, Wanwisa Khunawattanakul
Rok vydání: 2010
Předmět:
musculoskeletal diseases
Diclofenac
Materials science
Surface Properties
Chemistry
Pharmaceutical
Drug Compounding
Composite number
Magnesium Compounds
Pharmaceutical Science
Permeability
Nanocomposites
Diffusion
Chitosan
chemistry.chemical_compound
Adsorption
Tensile Strength
Spectroscopy
Fourier Transform Infrared
Ultimate tensile strength
Technology
Pharmaceutical
Magnesium
Aluminum Compounds
Pliability
Acetaminophen
chemistry.chemical_classification
Drug Carriers
Nanocomposite
Calorimetry
Differential Scanning
Silicates
fungi
Temperature
Water
Hydrogen Bonding
Polymer
Aluminium silicate
Permeation
Propranolol
body regions
Solubility
chemistry
Chemical engineering
Aluminum Silicates
lipids (amino acids
peptides
and proteins)
Powder Diffraction
hormones
hormone substitutes
and hormone antagonists
Tablets
Zdroj: International Journal of Pharmaceutics. 393:220-230
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2010.04.007
Popis: Chitosan-magnesium aluminum silicate (CS-MAS) films were prepared and the effects of MAS content and heat treatment of the CS-MAS dispersion before film casting on the physicochemical and drug permeability properties of the films were investigated. CS could interact with MAS via electrostatic interaction and intermolecular hydrogen bonding mechanisms, resulting in nanocomposite formation, for which it was not necessary to apply the heat treatment on the composite dispersions. The nature of the exfoliated and intercalated nanocomposite films formed was depended on the MAS content added. The heat treatment on the composite dispersions caused an increase in tensile strength, but reduced %elongation of the CS-MAS nanocomposite films. The exfoliated nanocomposite films showed higher flexibility, water uptake, and drug permeability compared to the CS and intercalated CS-MAS nanocomposite films. At higher MAS content, the CS-MAS films prepared using heat treatment had a lower water uptake, resulting in lower drug permeability when compared with those prepared using non-heated dispersions. The permeation mechanism of non-electrolyte and negatively charged drugs across the CS-MAS nanocomposite films was predominantly controlled by diffusion in water-filled microchannels, whereas both adsorption onto MAS and diffusion processes occurred concurrently for the film permeation of positively charged drugs. The findings of this study suggest that CS-MAS nanocomposite films can be formed without heating of the composite dispersion before casting. CS-MAS nanocomposites showed strong potential to be used as a film former for coated tablets intended for modulating drug release.
Databáze: OpenAIRE
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