Intracellular alkalosis during hypoxia in newborn mouse brain in the presence of systemic acidosis: a phosphorus magnetic resonance spectroscopic study
| Autor: | Tetsuo Nishiki, Nobuto Mitsufuji, Tadashi Sawada, Masashi Tominaga, Sozo Okano, Hiroshi Yoshioka |
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| Rok vydání: | 1995 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Magnetic Resonance Spectroscopy Alkalosis Phosphocreatine pCO2 Phosphates Mice chemistry.chemical_compound Adenosine Triphosphate Developmental Neuroscience Hypocapnia Internal medicine medicine Animals Hypoxia Acidosis Brain Chemistry Mice Inbred ICR Phosphorus Isotopes General Medicine Venous blood Hydrogen-Ion Concentration Hypoxia (medical) medicine.disease Endocrinology Animals Newborn chemistry Pediatrics Perinatology and Child Health Neurology (clinical) Blood Gas Analysis medicine.symptom Energy Metabolism Intracellular |
| Zdroj: | Brain and Development. 17:256-260 |
| ISSN: | 0387-7604 |
| DOI: | 10.1016/0387-7604(95)00053-e |
| Popis: | We investigated the in vivo changes in cerebral energy metabolism and pHi in newborn mice noninvasively during 8 h of hypoxia with FiO2 = 5%, using phosphorus magnetic resonance spectroscopy continuously. The intracellular brain pH (pHi) increased from 7.20 +/- 0.03 to 7.36 +/- 0.03 (P < 0.05) at 1 h of hypoxia and then decreased gradually. On the other hand, the mixed arterial and venous blood pH decreased gradually during hypoxia, reaching a minimum value of 7.16 +/- 0.01 at the end of the hypoxia. There was no significant difference in PCO2 between control (47.4 +/- 0.8 mm Hg) and 1-h hypoxic (49.0 +/- 1.1 mm Hg) mice. The blood glucose concentration was significantly increased at 1 h of hypoxia. These results indicate that the alkaline shift in pHi during hypoxia was caused neither by systemic alkalosis due to hypocapnia nor hypoglycemia. |
| Databáze: | OpenAIRE |
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