Status of the microsomal mixed function oxidase system in the intestine, lungs and kidneys of hamsters during infection with Ancylostoma ceylanicum
| Autor: | J. C. Katiyar, O.P. Shukla, S. Ghatak, P.K.S. Visen, S. Mukerjee, Babu L. Tekwani, L.M. Tripathi |
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| Rok vydání: | 1988 |
| Předmět: |
Male
Cytochrome-B(5) Reductase Cytochrome Reductase Biology Kidney Ancylostomiasis Mixed Function Oxygenases chemistry.chemical_compound Cricetinae Microsomes Animals Lung Heme Ancylostoma ceylanicum Mesocricetus Cytochrome b biology.organism_classification Molecular biology Jejunum Infectious Diseases chemistry Biochemistry Microsome biology.protein Pyrene Parasitology |
| Zdroj: | International Journal for Parasitology. 18:11-14 |
| ISSN: | 0020-7519 |
| DOI: | 10.1016/0020-7519(88)90029-x |
| Popis: | Tekwani B. L., Tripathi L. M., Mukerjee S., Visen P. K. S., Katiyar J. C., Shukla O. P. and Ghatak S. 1988. Status of the microsomal mixed function oxidase system in the intestine, lungs and kidneys of hamsters during infection with Ancylostoma ceylanicum . International Journal for Parasitology 18 : 11–14. Infection of golden hamsters with Ancylostoma ceylanicum causes significant alterations in microsomal cytochrome P-450 and associated components in intestine, lungs and kidneys. In intestinal microsomes, cytochrome P-450, cytochrome b 5 , heme, cytochrome b 5 reductase, NADPH-cytochrome c reductase and benzo(a)pyrene hydroxylase decreased considerably. This generalized damage in jejunal microsomes appears to be due to marked pathological lesions in this tissue. Lung microsomes exhibited a decrease in cytochrome P-450, heme and benzo(a)pyrene hydroxylase, while cytochrome b 5 , and cytochrome b 5 reductase were not significantly affected. Renal microsomes showed elevation in cytochrome P-450 and benzo(a)pyrene hydroxylase, while other associated components remained unaffected. |
| Databáze: | OpenAIRE |
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