Antioxidant and protective effects of Phytocee™against carbon tetrachloride-induced oxidative stress
| Autor: | Amit Agarwal, Sridhar Mutyala, Uma Radhakrishnan, Joshua Allan Joseph, K.S. Goudar, Usha Parackal Thachappully Ayyappan |
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| Rok vydání: | 2015 |
| Předmět: |
malondialdehyde
Antioxidant medicine.medical_treatment Pharmacology medicine.disease_cause digestive system General Biochemistry Genetics and Molecular Biology Superoxide dismutase chemistry.chemical_compound medicine oxidative stress Vitamin C biology General Medicine Glutathione Malondialdehyde Phytocee™ digestive system diseases chemistry Biochemistry Catalase Carbon tetrachloride biology.protein carbon tetrachloride Oxidative stress Research Article |
| Zdroj: | Journal of Natural Science, Biology, and Medicine |
| ISSN: | 0976-9668 |
| Popis: | Background: This study evaluated the antioxidant potential of a polyherbal formulation (Phytocee ™ ) in the rodent model. Materials and Methods: Four groups of rats ( n = 6) were pretreated with Vitamin C (20 mg/kg) or Phytocee ™ (20, 100, and 200 mg/kg), respectively for 10 days. Oxidative stress in rat liver was induced by administration of carbon tetrachloride (CCl 4 ) at 2 ml/kg as a single dose orally to all groups except the vehicle control group. After 24 h of administration of CCl 4 , hepatic levels of malondialdehyde (MDA), serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), hepatic superoxide dismutase (SOD), catalase, and reduced glutathione (GSH) levels were evaluated. Results: Phytocee ™ administered groups at all the dose levels significantly reduced the hepatic MDA, serum ALT and AST levels with a marked increase in hepatic SOD and catalase as compared with CCl 4 treated group. Conclusion: The findings suggest that Phytocee ™ markedly reversed the effects of CCl 4 induced oxidative stress and can be used as an antioxidant feed supplement. |
| Databáze: | OpenAIRE |
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