Copper metabolism in mottled mouse mutants. The effect of copper therapy on lysyl oxidase activity in brindled (Mobr) mice
| Autor: | P M Royce, David M. Danks, J Camakaris, Jeffrey R. Mann |
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| Rok vydání: | 1982 |
| Předmět: |
History
Sebacic acid Copper metabolism Mutant chemistry.chemical_element Education Protein-Lysine 6-Oxidase Subcutaneous injection chemistry.chemical_compound Mice Lysyl oxidase activity Animals Humans Menkes Kinky Hair Syndrome Amino acid oxidoreductases Skin Brain Diseases Metabolic Copper Molecular biology Mice Mutant Strains Computer Science Applications chemistry Biochemistry Amino Acid Oxidoreductases Research Article |
| Zdroj: | The Biochemical journal. 202(2) |
| ISSN: | 0264-6021 |
| Popis: | Lysyl oxidase activity in extracts of skin from 1-day-old Mobr/Y mice was found to be between 50 and 60% of that in corresponding extracts from littermate +/Y mice of the same age. It was increased to 84-150% of that in the latter by prior treatment of the Mobr/Y mice at 7 days of age with a single subcutaneous injection of 50 micrograms of copper, retained as Cu+ in an alkyl polyether/sebacic acid solution. This suggests that in this form the copper is able to by-pass the block in copper metabolism and is deliverable to copper-requiring processes. |
| Databáze: | OpenAIRE |
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