Galectin-3 levels are associated with right ventricular functional and morphologic changes in pulmonary arterial hypertension

Autor: Lori J. Silveira, Brett E. Fenster, Jamey Smyser, Luis Lasalvia, Kevin K. Brown, J. Kern Buckner, Joyce D. Schroeder
Rok vydání: 2015
Předmět:
medicine.medical_specialty
Galectin 3
Galectins
Hypertension
Pulmonary
Ventricular Dysfunction
Right
Magnetic Resonance Imaging
Cine
Pilot Projects
030204 cardiovascular system & hematology
Multimodal Imaging
Muscle hypertrophy
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Internal medicine
medicine
Ventricular Pressure
Humans
Prospective Studies
Hyaluronic Acid
End-systolic volume
Aged
Echocardiography
Doppler
Pulsed
Ejection fraction
Tissue Inhibitor of Metalloproteinase-1
Hypertrophy
Right Ventricular
Ventricular Remodeling
business.industry
Anatomy
Blood Proteins
Middle Aged
Fibrosis
Peptide Fragments
Up-Regulation
medicine.anatomical_structure
Blood pressure
030228 respiratory system
Ventricle
Galectin-3
Cardiology
Ventricular Function
Right
End-diastolic volume
Biomarker (medicine)
Cardiology and Cardiovascular Medicine
business
Biomarkers
Procollagen
Zdroj: Heart and vessels. 31(6)
ISSN: 1615-2573
Popis: The response of the right ventricle (RV) to pulmonary arterial hypertension (PAH) involves changes in contractile function, chamber size, hypertrophy, and extracellular matrix (ECM). Galectin-3 (Gal-3) is a mediator of myocardial ECM metabolism and biomarker for left heart remodeling, yet its ability to reflect RV remodeling is unknown. We hypothesized that serum Gal-3 levels correlate with RV morphology and function in PAH, and that Gal-3 is associated with circulating markers of ECM. Fifteen subjects with PAH and 10 age-matched controls underwent same-day echocardiography, cardiac magnetic resonance (CMR) imaging, and phlebotomy for Gal-3 and ECM biomarkers including N-terminal propeptide of type III collagen type (PIIINP), tissue inhibitor of metalloproteinase-1 (TIMP-1), and hyaluronic acid (HA). RV ejection fraction, end diastolic volume index, end systolic volume index, and mass index were calculated using CMR. Echocardiography was used to estimate RV systolic pressure and measure RV strain. Serum Gal-3, TIMP-1, and HA levels were all significantly increased in PAH subjects when compared to controls. Gal-3 correlated with RV ejection fraction (ρ -0.44, p 0.03), end diastolic volume index (ρ 0.42, p 0.03), end systolic volume index (ρ 0.44, p 0.027), mass index (ρ 0.47, p 0.016), systolic pressure (ρ 0.55, p < 0.001), and strain (ρ 0.43, p 0.03). Gal-3 levels positively correlated with the ECM markers TIMP-1 and HA but not with PIIINP. In conclusion, Gal-3 levels are associated with multiple indices of RV function and morphology. Gal-3 may represent a novel biomarker for RV remodeling and associated ECM turnover in PAH.
Databáze: OpenAIRE
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