Sit down, relax and unwind: structural insights into RecQ helicase mechanisms
| Autor: | Michael P. Killoran, James L. Keck |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
DNA Replication
congenital hereditary and neonatal diseases and abnormalities RecQ helicase Computational biology Multifunctional Enzymes 03 medical and health sciences chemistry.chemical_compound Adenosine Triphosphate Protein structure Genetics Molecular motor Humans Survey and Summary 030304 developmental biology Adenosine Triphosphatases 0303 health sciences RecQ Helicases biology Hydrolysis 030302 biochemistry & molecular biology DNA Helicases Rothmund-Thomson Syndrome DNA replication nutritional and metabolic diseases Helicase Protein Structure Tertiary chemistry Nucleic acid biology.protein Werner Syndrome Bloom Syndrome DNA |
| Zdroj: | Nucleic Acids Research |
| ISSN: | 1362-4962 0305-1048 |
| DOI: | 10.1093/nar/gkl538 |
| Popis: | Helicases are specialized molecular motors that separate duplex nucleic acids into single strands. The RecQ family of helicases functions at the interface of DNA replication, recombination and repair in bacterial and eukaryotic cells. They are key, multifunctional enzymes that have been linked to three human diseases: Bloom's, Werner's and Rothmund-Thomson's syndromes. This review summarizes recent studies that relate the structures of RecQ proteins to their biochemical activities. |
| Databáze: | OpenAIRE |
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