Use, timing and factors associated with tracheal intubation in septic shock: a prospective multicentric observational study

Autor:	P. Labroca, K. Merouani, Frédéric Pène, S. Jacquier, Eddy Lebas, M. Commereuc, A. Delbove, C. Marois, Nicolas Lerolle, Caroline Bornstain, S. Vally, Nicolas Terzi, Nicolas Chudeau, P. Bouju, G. Ledoux, P. Y. Egreteau, A. Robert, Jean-François Hamel, Mai-Anh Nay, F. Roche-Campo, René Robert, Vincent Peigne, J. Lorber, Frédéric Martino, M. Debarre, F. Benezit, F. Bagate, M. Saint-Martin, T. Balzer, Stéphane Gaudry, Sigismond Lasocki, C. Darreau, Laurent Camous
Rok vydání:	2020
Předmět:	medicine.medical_specialty medicine.medical_treatment Critical Care and Intensive Care Medicine 03 medical and health sciences 0302 clinical medicine Mechanical ventilation Anesthesiology Septic shock medicine Intubation 030212 general & internal medicine business.industry Research Tracheal intubation lcsh:Medical emergencies. Critical care. Intensive care. First aid Glasgow Coma Scale 030208 emergency & critical care medicine lcsh:RC86-88.9 medicine.disease Clinical trial Anesthesia Observational study business
Zdroj:	Annals of Intensive Care Annals of Intensive Care, Vol 10, Iss 1, Pp 1-10 (2020)
ISSN:	2110-5820
Popis:	Background No recommendation exists about the timing and setting for tracheal intubation and mechanical ventilation in septic shock. Patients and methods This prospective multicenter observational study was conducted in 30 ICUs in France and Spain. All consecutive patients presenting with septic shock were eligible. The use of tracheal intubation was described across the participating ICUs. A multivariate analysis was performed to identify parameters associated with early intubation (before H8 following vasopressor onset). Results Eight hundred and fifty-nine patients were enrolled. Two hundred and nine patients were intubated early (24%, range 4.5–47%), across the 18 centers with at least 20 patients included. The cumulative intubation rate during the ICU stay was 324/859 (38%, range 14–65%). In the multivariate analysis, seven parameters were significantly associated with early intubation and ranked as follows by decreasing weight: Glasgow score, center effect, use of accessory respiratory muscles, lactate level, vasopressor dose, pH and inability to clear tracheal secretions. Global R-square of the model was only 60% indicating that 40% of the variability of the intubation process was related to other parameters than those entered in this analysis. Conclusion Neurological, respiratory and hemodynamic parameters only partially explained the use of tracheal intubation in septic shock patients. Center effect was important. Finally, a vast part of the variability of intubation remained unexplained by patient characteristics. Trial registration Clinical trials NCT02780466, registered on May 23, 2016. https://clinicaltrials.gov/ct2/show/NCT02780466?term=intubatic&draw=2&rank=1.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88be394ba0caa7c14f5437fb9fa6517f https://pubmed.ncbi.nlm.nih.gov/32449053 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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