Thioredoxin 1 (Trx1) is associated with poor prognosis in clear cell renal cell carcinoma (ccRCC): an example for the crucial role of redox signaling in ccRCC
| Autor: | Marcus Scharpf, Jens Bedke, Silvia Ribback, Manuela Gellert, Nils Kroeger, Stefan Winter, Elke Schaeffeler, Matthias Schwab, Viktoria Stühler, Christopher Horst Lillig, Tobias Klatte, Martin Burchardt |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty Poor prognosis DNA Copy Number Variations Urology Thioredoxins Internal medicine medicine Biomarkers Tumor Humans Copy-number variation Progression-free survival Carcinoma Renal Cell chemistry.chemical_classification Reactive oxygen species business.industry medicine.disease Prognosis Kidney Neoplasms Clear cell renal cell carcinoma chemistry Tumor necrosis factor alpha Thioredoxin business Kidney cancer Oxidation-Reduction |
| Zdroj: | World journal of urology. 40(3) |
| ISSN: | 1433-8726 |
| Popis: | Purpose Thioredoxins are major regulatory proteins of oxidative signaling. Trx1 is the most prominent thioredoxin and, therefore, the current study sought to evaluate the prognostic role of Trx1 in ccRCC. Methods and patients A tissue micro-array (TMA) study was carried out to evaluate the association of Trx1 with clinicopathological features and survival outcome. Data from the Cancer Genome Atlas (TCGA) were evaluated for the association of characteristics in the Trx1 gene with clinicopathological features and survival outcome. Results In the TMA, patients with ccRCC that had high Trx1 levels had lower T stages (p p = 0.018), lower nuclear grades (p p = 0.037) or sarcomatoid features (p = 0.008). Patients with a combined score of ≥ 10 had better DSS than patients with a low combined score of p p = 0.001), and progression free survival (p = 0.001) when compared to patients with ccRCCs without copy number variations (CNV) or gains. Conclusion The current study suggests a possible role of Trx1 in the tumor biology of ccRCC and thus, the current study strongly advises in depth investigations of redox signaling pathways in ccRCC. |
| Databáze: | OpenAIRE |
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